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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6318.12

Abstract

Background: Misoprostol is being in use as an agent for preinduction cervical ripening. But still the ideal dosage, route of administration of this agent is not exactly known.

Aim: To evaluate the efficacy and safety of 25 mcg and 50 mcg intravaginal misoprostol for labor induction.

Materials and Methods: We carried our study on 120 low-risk singleton pregnancies reported to the antenatal ward of Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India. The sample was categorized in to two groups, group A women were given 25 mcg (n = 60) and group B women received 50 mcg (n = 60) of intravaginal misoprostol. The dosage was repeated every four hours (limiting maximum number of doses to 3 doses). Induction vaginal delivery interval was the main outcome measure. Results: Most of the patients of both groups were 20 to 25 years. We found primigravidae cases in Group A and B to be 75 and 55% respectively. The percentage of cases of term pregnancies was 53.33% and 40% cases in group A and B respectively. Oxytocin augmentation was need in 41.66% cases (Group A) and 33.33% cases(Group B). After six hours, Modified Bishop’s score was 7-10 in 70% (Group A) and 71.67% (Group B) cases. Vaginal deliveries were more in Group A (66.66%) than Group B (50%). Cesarean section rate was more in group B (36.66%) when compared with group A (16.67%).

Conclusion: 25 mcg misoprostol is safe and successful for labor induction.

Keywords: Cervical Ripening; Labor Induction; Prostaglandin; Vaginal Misoprostol.

 

Corresponding Author : Padmalatha, Associate Professor, Department of Obstetrics & Gynaecology, Chalemedaanand Rao Institute of Medical Sciences, Karimnagar District, Telangana State 505001, India.