Objectives: 1. Estimation of lipid profile parameters including triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol and apolipoprotein A in both cases of carcinoma cervix and healthy controls. 2. Estimation of association of lipid parameters in cases with carcinoma cervix of various clinical stages. Materials and Methods: A total number of 60 women were recruited in our study. Out of these 60 women, 30 were cases and 30 were healthy controls. The 30 cases were clinically and histologically confined cases of carcinoma cervix of various stages. The 30 controls were matched with cases for age and BMI. The present comparative case control study was conducted at R. L. Jalappa Hospital and Research Centre attached to Sri Devaraj Urs Academy of Higher Education,Tamaka, Kolar between January 2014 to June 2015. Lipid parameters were analyzed using Vitros 250 dry chemistry auto analyzer from Johnson and Johnson. Serum apolipoprotein A was analyzed by immunoturbidimetry. Results: The mean age for cases was 56.5± 12.03 and mean age for controls was 55.8± 10.16.Majority of patients 14(46.7%) presented with three main symptoms i.e. offensive vaginal discharge, loss of appetite, weight loss. Majority of the cases, 18(60%) were postmenopausal women..Out of these 30 women who undergone biopsy, 28(96.7%) had squamous cell carcinoma and 2 (3.3%) had adenocarcinoma. Amongst 30 cases, 9 patients (30%) had well differentiated, 19 had moderately differentiated and 2 had poorly differentiated carcinoma. Majority of patients 17(56.7%) presented with stage IIIB. The mean serum HDL, LDL, triglycerides, total cholesterol were 35.67± 8.16, 79.47±14.97, 107.77±28.11,131.7±20.32 in cases respectively. The mean serumHDL, LDL, Triglycerides, total cholesterol were 50.47±7.04, 117.57±22.89, 183.57±32.93, 176.3±24.24 in controls respectively. The mean serum apolipoprotein A levels in cases (169.19 ± 24.60) were increased when compared to controls. Conclusion: The mean serum HDL cholesterol, LDL cholesterol, triglycerides and total cholesterol were found to be significantly lower in patients with cervical cancer when compared to health controls. The mean serum Apolipoprotein A was found to be significantly elevated in cases when compared to healthy controls. 

Keywords: Lipid Profile; Cancer Cervix; Apolipoprotein A.