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Indian Journal of Obstetrics and Gynecology

Volume  4, Issue 2, May-Aug 2016, Pages 141-144
 

Original Article

LDH A Prognostic Marker for Preeclampsia: An Observational Study

Uma Pandey

Associate Professor, Department of Obstetrics & Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.4216.15

Abstract

  Objective: Elevated LDH levels can be used to help in decision­making and management to improve the maternal and fetal outcome, as elevated LDH levels are indicative cellular damage and dysfunction. Elevated LDH levels indirectly reflect severity of preeclampsia. Materials and Methods: This retrospective observational study was conducted in a tertiary referral hospital of
Northern India (Banaras Hindu University), which has a wide catchment area. We wanted to find out the role of LDH levels in explaining prognosis to the mother and also in prediction of adverse outcome of feto­maternal outcomes. Results: Total 46 women. 31(67.39%) were nonsevere gestational hypertension (NSGH) and 15 (32.60%) were severe gestational hypertension (SGH). There were 3women out of the SGH category who had eclampsia. LDH levels were >800 in all three eclamptic women. LDH was 600­800 in 83.33% of severe gestational hypertension group (SGH). In nonsevere gestational hypertension (NSGH) LDH level was <600 in 64.51%. In the group with LDH levels of 600­ 800 one case of Abruptio placentae was diagnosed. The group with LDH>800, they all had eclampsia, there was thrombocytopaenia/ HELLP in all 3 cases and oliguria found in 2 pregnant women. Fetal growth restriction was found in 2 cases. Conclusion: he study 
concludes that LDH levels have significant association with increasing maternal and fetal morbidities in patients with severe gestational hypertension. 

Keywords: Lactic Dehydrogenase; Severe Preeclampsia; Eclampsia; Severe Gestational Hypertension, Nonsevere Gestational Hypertension.


Corresponding Author : Uma Pandey