AbstractIntroduction: In preeclampsia, there is failure of estrogen production due to placental dysfunction resulting in lowering of TBG, TT3, TT4 along with growth retardation of the foetus. It has been shown that individuals with subclinical hypothyroidism have impaired endothelium derived vasodilatation from diminished nitric oxide secretion that is restored after thyroxine (T4) replacement. The present study is proposed to evaluate the association of preeclampsia and thyroid dysfunction in pregnant women and perinatal outcome. Methods: The present study was carried out on pregnant women with preeclampsia admitted to or attending the Outpatient Department of Obstetrics and Gynecology GSL medical college and hospital, between June 1st 2018 to May 31st 2019. Similar number of age & parity-matched normotensive pregnant women served as controls. Battery of investigations focusing on thyroid hormones were performed and both groups were compared in terms of thyroid status, perinatal outcome and complications. Results: Incidence of hypothyroidism is high but mostly subclinical.Women with preeclampsia had higher TT3, TT4 levels as compared to non pregnant women. TSH levels were higher significantly higher in preeclamptic women than normotensive pregnant women. A significant negative correlation was observed between birth weight and TSH levels serum albumin and TSH levels in preeclamptic women. Conclusion: These findings indicate that there is state of hypothyroxinemia in normal pregnancy and in preeclampsia. Identification of changes in thyroid hormones in preeclampsia might be of help in preventing the occurrence of preeclampsia.