AbstractIntroduction: Rubella is a febrile rash illness affecting children and adults: however, in women affected early during pregnancy, it can severely impact the fetus resulting in miscarriage, fetal death, or an infant born with a group of disabling conditions collectively called Congenital Rubella Syndrome (CRS). Immunity to rubella in the form of rubella specific antibodies in pregnant women can indirectly indicate the risk of acquiring CRS. The susceptibility of women in reproductive age group should be the first requirement in order to set plan for the
prevention of rubella infection and its transmission. Aim: To determine the seroprevalence of rubella specific immunoglobulin G antibodies in women of 18–40 years age group. Settings and Designs: It is a cross sectional observational study conducted at a tertiary care hospital. Materials and Methods: Blood sample collected from 150 women of reproductive age group was subjected to architect system, with the chemiluminiscent microparticle immunoassay for detection of Rubella
IgG. Statistical Snalysis: The results obtained were tabulated and chi-square test applied. Results and Conclusions: 91.33% women were seropositive for rubella IgG antibodies. Since the seroprevalence is high, the susceptibility to rubella infection during pregnancy is low and hence the risk of CRS in the population is also low.