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RFP Journal of Dermatology

Volume  4, Issue 1, January-June 2019, Pages 25-27
 

Original Article

Autologous Serum Skin Test in Chronic Urticaria

Vijetha Rai1, Karthik Raju2, Anudeep Sriram3, Shubha Dhanprakash4

1Assistant Professor, 3Senior Resident, 4Junior Resident, Department of Dermatology, Venereology, Leprology, Srinivas Institute of Medical College and Research Center, MukkaSuratkal, Pandeshwar, Mangaluru, Karnataka 575001, India. 2Consultant Dermatologist, Rich eld Clinic, Hyderabad, India.

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Abstract

Background: Chronic urticaria is a distressing condition which affects the quality of life of patients. Majority of chronic urticaria patients have no external cause and termed as chronic idiopathic urticaria. Approximately 30-40% of patients with chronic idiopathic urticaria have autoimmune urticaria. Asst is a simple inexpensive test which helps to classify chronic urticaria into idiopathic urticaria and autoimmune urticaria. Aims: To identify autoimmune urticaria amongst the chronic idiopathic urticaria. Methods: A total of 100 cases of chronic urticaria, attending the skin opd from march to February were taken up for the study. After a detailed clinical history and examination laboratory investigations like Complete haemogram, Blood sugars, Erythrocyte Sedimentation Rate (ESR), Absolute eosinophil count (AEC) was sent for all the patients. ASST was done. A positive test was defined as a serum-induced wheal response with a diameter of 1.5 mm or more than the saline induced response at 30 minutes. Results: Of all the patients studied 41% of the patients showed a positive reaction. Most of whom were females and in the age group of 21-30 years. The mean urticaria activity score was 5.11 in the ASST positive patients compared to 4.39 in the ASST negative group. In the ASST positive group, 80.48% had daily occurrence of lesions while 62.71% of the asst negative group got lesions daily. Patients with positive ASST had larger extent of body involvement. Conclusion: We concluded that autoimmune urticaria has greater frequency and larger extent and higher urticarial activity score than other types of urticaria.

Keywords: Chronic urticaria; ASST; Autoimmune urticaria.


Corresponding Author : Vijetha Rai