ABS RAC
Manymedicationsarenowadministeredorally&howeertheyarenotaseffectieas
theyshould e.Beyondthelocalapplicationsite,transdermaldelierytechnology
is eing e*ploredtotreatawide range ofdiseases.Becauseof reducedfirstpass
meta olism,aoidanceofanadersegastrointestinalenironment,andthepotential
toproidee*tendedandregulateddrugdeliery,transdermaldrugadministration
offerssu stantial enefitsoeroraltreatment.Transdermaldrugdelierysystems
(TDDS)aretopically appliedpatchesthatreleasemedicationsfor systemiceffects
atapredeterminedandregulatedrate.Itworks yputting amedicationinsidea
patchandwearingitforalongtimeontheskin.Asaresult,asteadyconcentration
ofmedication remains inthe loodstreamfor an e*tendedperiod oftime. TDDS
products include Scopolamine, Nicotine, Testosterone, Fentanyl, and Clonidine.
Numerousactiecompoundswitharia lemolecularsi3eandstructurecannot e
maintainedintransdermalform,despitetheirmany enefits.
Key(ords)Transdermalpatch,Skin,Permeationpathways,Matri*.