Alprazolam is as a high-potency benzodiazepine drug that is often encountered in medico-legal cases of drug facilitated sexual assaults, robberies and stupefying activities. Its detection by traditional color tests and thin layer chromatography is routinely done in forensic science laboratories using food and biological samples. In this study we have modified a color test and have tested various new solvent systems for TLC method of analysis of Alprazolam and have found that these can be successfully employed in routine analyses in FSLs so as to produce more effective results.