AbstractScientometric analysis of human DNA research output of the USA has been studied from 7264 research papers published during 1984-2012 that indexed in Scopus. The study reveals that the highest number of 337 papers or 4.64% published in 1996, followed by 314 (4.32%) papers in 1999. According to the Relative Growth Rate and Doubling Time of the publications value measured from 0.03 in 2010 and 2011 to 0.087 in 1985; from 0.80 in 1985 to 23.10 in 2010 and 2011 respectively found in this study. Among the document types, journal articles were the highest numbers with 7210 papers or 99.26%. From this study, it is observed that the Journal of Biological Chemistry has published with 529 research papers and find top position which is accounted for 7.28% of the total articles. Among 128 institutions, the National Cancer Institute has published 322 papers or 4.43% during the study period. It is found that the degree of Collaboration of authors from 0.99 in 2003 to 0.66 in 2010 to which is to be fluctuating trend appears during the study period. Overall, there is an increasing trend has been identified on multi authored papers in human DNA research by the US during the period. In this study, it is found that 29% papers are internationally, collaborating and UK is the major collaborator with the USA in 270 papers.