The study aimed to assess the Nuclear Medicine research output from 1991 to 2020. Totally 12632 data were mainly collected from the web of science database. These data were downloaded and analyzed by using MS Excel as per the objective of the study. The researcher has been done to discover the development and properties of large data output is the global level. The year-wise distribution of Nuclear Medicine research. The study revealed the year 2020 occupied the first position with 771 (6.10) records, followed by the year 2019 with 677(5.36) records compared to 1991 to 2020.Author-wise distribution of publication showed that Rubello, D occupied the first position with 81(0.64%) and Signore, A is the second position with 72 (0.57%) and others. In this study single author contributed 1776 (14.06) papers in this study. The relative growth rate and doubling time the growth of publications decreased trend, the corresponding doubling time was increased.