Background: It a great challenge which requires great efforts to treat the patient with burn injury. Immediate treatment significantly improves mortality rates. Management of a burn case usually involve, appropriate fluid resuscitation, attainment of resuscitation targets using consensus formulas for initial fluid administration, topical agents to control pain, reduction of fluid loss as well to prevent bacterial growth. Objective: our aim was to look for the evidence of effectiveness of HBOT and the patient’s satisfaction improvement due to reduction in wound pain. Study Design: Study carried out was prospective case control study. Place of Study: Prana HBO Centre, located in the Northern parts of Mumbai, in India. Methods: In group I in comprised of 22 patients with burn injury who got regular HBO therapy. HBO therapy was given with compressed with air at a pressure of 2.5 atmosphere absolute (ata). At this pressure the patient breathed 100% oxygen via facial mask. The HBO therapy protocol included 90 minutes oxygen breathing at 2.5 ata, twice daily over 6 days. 20 sessions were performed for each patient. In group II patients with burn injury were 21 who also received burn treatments in our setup but without HBO therapy. Results and Discussion: The mean improvement in pain relief in group I was 4.9 ± 1.2 in comparison to group II which was 3.2 ± 0.85, comparatively improvement in pain score was significantly higher in group I and at par with group II. Hyperbaric Oxygen therapy can improve pain score and patient satisfaction in our study. However the possibility of cost effectiveness of the HBO therapy would need further discussion. Future, the clinical trials with large sample size and different types of burn injury shall be considered. Conclusion: Findings shows the beneficial effects of HBO therapy, as well suggests that the HBO therapy has a significant improvement in the pain relieve and satisfaction improvement. Hence, HBO therapy, as an adjuvant treatment, could be helpful for pain control and satisfaction associated with burn injuries.