Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. This review article gives an overview of cSSC in terms of etiology, pathophysiology, epidemiology, prognosis, clinical presentation, work up, treatment and highlights various guidelines like American College of Radiology, Scottish Intercollegiate Guidelines Network's, Dermatological Cooperative Oncology Group of the German Cancer Society, British Association of Dermatologists Guidelines for the management of cSSC.