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RFP Journal of Gerontology and Geriatric Nursing

Volume  3, Issue 2, July – December 2020, Pages 49-55


Original Article

Analysis of Insulin Resistance in Newly Detected and Thyroxine Supplemented Cases of Subclinical Hypothyroidism with Special Reference to Geriatric Population
Tejeswini Jayaram1, Poojitha Gavulla2, Pratibha Pereira3
1Associate Professor, Department of Geriatric Medicine, 2Junior Resident, Department of Internal Medicine, 3Professor and Head, Department of Geriatric Medicine, Jagadguru Sri Shivarathreeshwara AHER, Mysuru 570015, Karnataka, India.
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Context: Thyroid hormone causes significant changes on the regulation of glucose homeostasis including IR [Insulin resistance]. There are no remarkable studies researching IR in geriatric and nongeriatric patients of Subclinical Hypothyroidism [SCH] and the changes observed with thyroxine treatment. Aims: To analyse Insulin resistance in newly detected SCH and Thyroxine supplemented cases of SCH and its comparison in elderly. Settings and Design: It was an observational cross-sectional hospital-based study. Methods and Material: It involved 120 SCH patients aged more than 18 years. Group A comprised 60 cases of newly diagnosed SCH cases and Group B was 60 SCH patients on thyroxine treatment for at least 3 months. For both the groups FBS, Fasting Insulin levels and HOMA IR [Homeostatic model assessment -estimated Insulin resistance] was calculated. Statistical analysis used: Inferential statistics was done using Mann Whitney U test and Pearson product moment correlation tests. Results: Group A consisted of 17 geriatric patients and group B had 19. Females made up 71% in group A and 83% in group B in both age groups. Comparison of Fasting Insulin levels and HOMA IR between A and B groups showed a significant difference (at 0.01 level). The duration of treatment had inverse correlation with HOMA IR with p=0.007 in non-geriatric population but not in geriatric population. Conclusions: Insulin resistance is present substantially in patients with newly detected SCH and decreases after administration of thyroxine in both geriatric and nongeriatric population. Keywords: BMI; Fasting Insulin levels; Geriatric; HOMA IR; Non-geriatric; Subclinical hypothyroidism;

Corresponding Author : Tejeswini Jayaram, Associate Professor, Department of Geriatric Medicine, Jagadguru Sri Shivarathreeshwara AHER, Mysuru 570015, Karnataka, India.