Pulmonary embolism has a large spectrum of clinical presentations ranging from asymptomatic to sudden death. Sometimes presentation of pulmonary embolism is not classical and rather atypical, like paradoxical embolism. We are presenting a case of pulmonary embolism leading to paradoxical embolism (PDE) presented with seizure disorder due to ischemic stroke and acute life-threatening limb ischemia. In this clinical scenario, early suspicion is very important for prompt therapeutic interventions. This patient was diagnosed timely and managed successfully.