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Indian Journal of Emergency Medicine

Volume  6, Issue 1, January-March 2020, Pages 15-18
 

Original Article

Role of Initial Procalcitonin in Predicting Mortality in Sepsis

Sona Kurian1, Naveen Mohan2, Gireesh Kumar KP3, Bharath Prasad4, Dhanasekharan BS5, Sreekrishnan TP6, Arun Kumar7

1PG Student, 2,4,6,7Assistant Professor, 3Professor and Head, 5Professor Department of Emergency Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala 682041, India.

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.6120.2

Abstract

Context: There exists a deficiency in literature regarding the importance of procalcitonin in predicting mortality in sepsis patients. Aim: To determine the role of initial procalcitonin in predicting 7-day mortality in sepsis patients. Materials and methods: A prospective observational study was conducted on 200 sepsis patients admitted to the Emergency Department of a Medical College Hospital at Kochi. Blood culture samples and serum procalcitonin samples were withdrawn immediately and sent to lab. Mortality data of those patients were charted at the end of 7 days. Procalcitonin values were compared in both survivors and non survivors using paired Student t-test. p < 0.05 was accepted as statistically significant. Results: Out of the 200 patients, 131 were males and 69 were females. 17% expired and 83% survived at the end of 7 days of hospital stay. Mean procalcitonin value in survivors and non survivors were 16.41 ng/ml and 23.09 ng/ml respectively, which showed statistical significance [p-value = 0.026]. Conclusion: Initial procalcitonin plays an important role in predicting 7-day mortality in sepsis patients. 

Keywords: Sepsis; Procalcitonin; Mortality.


Corresponding Author : Naveen Mohan