AbstractClubbing is one of the ancient signs in clinical medicine since the time of Hippocrates. Its pathogenesis is said to be associated with platelet derived growth factor and vascular endothelial growth factor but exactly mechanism behind this is still unknown. We present a case of 55-years-old male admitted with complaints of fever, cough, pain and swelling of fingers. On examination he had Grade 4 clubbing and radiography revealed left upper lobe opacity with malignant features and subsequently bronchoscopy confirmed the diagnosis of squamous cell carcinoma.
Keywords: Clubbing, squamous cell carcinoma, HOA