ART methods are boon to infertile couples. Though ART methods are practiced widely in every country today. There is debate regarding their efficacy, cost-effectiveness, and risk factors. Women who conceive by ART have a high risk of maternal and perinatal complications such as ectopic pregnancy, pregnancy-induced hypertension, placenta previa, placental abruption, morbidly adherent placenta, preterm birth, and low birth weight. Gynecological complications associated with ART are OHHS, pelvic infection, and psychological and laboratory risks. Couples are encouraged to consider psychological counseling as an additional means of stress management. There is a higher incidence of multiple gestations in ART-associated pregnancies.