Collodion baby is a rare congenital defect of skin characterized by the presence of parchment like taut membrane which breaks on stretching which results in fissure formation. It is a very rare clinical condition, with a worldwide occurrence of 1: 300,000 births; being an uncommon dermatosis. We present a one day old collodion baby, our experience with this case taught us that careful attention to skin care, judicious use of skin care products, and meticulous attention to asepsis are of paramount importance when caring for an infant with collodion baby syndrome.

Keywords: Study; Research; Knowledge.