The Annual Parasite Incidence (API) of Malaria for Karnataka has been observed to have decreased from 0.12 in 2017 to 0.08 in 2018. Although the state has not reached zero Malaria cases in 2022, it is a good candidate for being among the first few states in the country to be able to achieve near elimination goals. Keywords: Malaria, Karnataka, API, Plasmodium vivax, Plasmodium falciparum.