The reconstructive ladder discusses progressively more difficult soft tissue coverage methods for wound coverage and healing. Regenerative medicine modalities can be added to conventional reconstructive methods, making it a hybrid reconstruction ladder, which may make it easier to achieve wound coverage at a lower 'rung'. We have used the hybrid reconstruction ladder in a patient with post traumatic degloving injury of lower limb with significant clinical improvement. Keywords: Hybrid reconstructive ladder, Degloving injury.