Aim: Our recent studies have shown that to investigate the concentration of hsCRP and Troponin-T in NSTEMI and STEMI patients. Myocardial infarction is the impairment of heart function due to inadequate blood flow to the heart compared to its need, caused by obstructive changes in the coronary circulation to the heart. Cardiac Troponin T is a twin filament protein which takes part in cardiac muscle contraction. Cardiac Troponin T is not normally present in serum unless cardiac cell necrosis has occurred. High sensitivity C-reactive protein, a systemic inflammatory marker is considered to be an independent risk marker of cardiovascular disease. Design/Methods: Acute myocardial infarction was studied in three groups, namely Control, NSTEMI and STEMI patients. Results: In NSTEMI and STEMI groups, mean serum levels of hsCRP and Troponin T is higher than the mean serum control group. Discussion: The serum levels of hsCRP and Troponin T were significantly increased in first, second and third day of NSTEMI and STEMI myocardial infarction patients compared with control normal subjects. Conclusions: The concentration of hsCRP and Troponin T is a useful index, not only in the diagnosis and prognosis, but also in some critical situations of taking some important decisions.