Background: Array of clinical studies showed the interlink between psoriasis and cardiovascular diseases. Fragmentation of QRS has been visualized during myocardial fibrosis in electro cardiogram. Objective: To evaluate the prevalence of fragmented QRS in psoriasis patients and compare with the control. Methods: In this study 38 psoriasis patients and 38 healthy people were evaluated by physical examination, 12-lead ECG, Severity of the psoriasis was evaluated by psoriasis area and severity. Further anthropometric parameters like waist circumference were measured. Biochemical evaluation fasting blood glucose, lipid profile and kidney profile were estimated. index (PASI). Results: In this mean PASI score was 9.91±1.25. The psoriasis subjects displayed higher waist circumference as that of the control (p<0.05), Further, the HDL level was significantly decreased in psoriasis patients as that of the control subjects (p<0.05). Further, frequency of fragmented QRS was higher in psoriasis patients as that of the control and was found to be statistically significant (p<0.05). Conclusion: Thus, based on the observation in the present study, the frequency of fragmented QRS were elevated in psoriasis patients as compared to normal subjects.