Introduction: Cardiomyopathies are a heterogeneous group of heart diseases. The present study aimed to assess the clinical profile of patients diagnosed with cardiomyopathy and factors affecting their clinical outcomes. Methodology: Diagnosed patients of cardiomyopathyadmitted in general medical ward in our department were included. Diagnosis of cardiomyopathy was made based on the history, clinical examination and echocardiography findings and classified as dilated or hypertrophic cardiomyopathy. Results: Dilated cardiomyopathy was seen in 92.5% of the patients. Ischemic etiology was observed in approximately half of all patients (47%). Other less common etiology of cardiomyopathy was peripartum, thyroid abnormality, HIV infection, alcoholism, infectious disease, tachycardia and drug induced. Breathlessness and fatigue were the two most common presenting complaints. Discharge from the medical ward was ordered 66% of the patients, 17% had to be transferred to ICU and 17% expired during the follow up period. Serum creatinine higher than 1.3 mg/dl and total bilirubin more than 1.2 mg/ dl were found to be significantly associated with patient being either transferred to ICU or die during the follow up period. Conclusions: Non-ischemic etiology was more prevalent and higher serum creatinine and total bilirubin were associated with poor clinical outcomes. Future research is suggested from the clinical standpoint as well as those involving molecular techniques.