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Journal of Pharmaceutical and Medicinal Chemistry

Volume  5, Issue 1, January-June 2019, Pages 13-17

 

Original Article

A Novel Stability Indicating RP-HPLC Method for Determination of Sofosbuvir in Bulk and Tablet Dosage Forms
G. Kumaraswamy1, D. Sudheer Kumar2, V. Ramya3
1Associate Professor 2Professor 3Student, Dept. of Pharmaceutical Analysis, Care College of Pharmacy, Warangal, Telangana 506006, India
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DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.5119.2

Abstract

The proposed work was accurate and precise stability indicating RP-HPLC method has been developed and validation of Sofosbuvir, in tablet dosage form. The separation was achieved on a Kromasil C18 (4.6×250 mm, 5µ) column using a mixture of Methanol: water (60: 40% v/v) as the mobile phase at a flow rate of 1.0 mL/min and detected 247 nm. The retention time of sofosbuvir 3.475 minutes. The linear responses in the concentration range of 10-60 µg/mL of Sofosbuvir. The method precision for the determination of assay was less than 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords: Sofosbuvir; RP-HPLC; Validation; Tablet dosage forms.


Corresponding Author : G. Kumaraswamy