Central venous catheters are associated with a risk of complications such as infection, thrombosis, and hemorrhage. Thus, good care performance is crucial in limiting these risks. Also, nurses are supposed to integrate evidence-based performance into their care to improve patient outcomes.

Objective(s): To assess nurse’s performance in preventing complications with central venous catheters and to evaluate the effcacy of an instructional program designed to improve nurses’ performance of preventing complications central venous catheter while working in critical care unit.

Methodology: The current study employed a quasi-experimental design, utilising a pre-test/post-test methodology to assess changes between the control group and the study group subsequent to the implementation of the instructional program. The research was conducted between 20 December 2023 and 20 May. The study population was all critical care unites staff nurses who were available during data collection time and worked in critical care unite for more than 1 year in Baghdad teaching hospitals.

Result: The instructional program demonstrates a remarkable impact on the performance of the nurses in the study group, as evidenced by the substantial and statistically signifcant difference in pre/post-test scores (p <.001).

Conclusion: The nurses’ performance in critical care about preventing complications central venous catheter had been enhanced subsequent to the implementation of the instructional program. It is recommended to conducting training courses for nurses within continuous education in hospital is crucial to increase nurses’ knowledge toward standard performance.