Background: Protein C, Protein S and Antithrombin III are negative regulators of coagulation. Homozygous protein C deficiency is a rare inherited disorder manifesting as neonatal purpura fulminans. A two week old female baby delivered at term, developed purpuric lesions over the left thigh and progressing to other areas. Investigations showed
negligible protein C level, besides meagre protein S and antithrombin III levels. The diagnosis of inherited combined protein C, protein S and antithrombin III deficiency was made. Conclusion: Genetic analysis will help in prenatal diagnosis in future pregnancies.

Keywords: Antithrombin III; Purpura fulminans; Thrombophilia.