Diabetes mellitus is a well-known lifestyle-associated metabolic disorder leading to microvascular and macrovascular complications as a consequence of insulin resistance and chronic hyperglycemia. Diabetic peripheral neuropathy (DPN) is the leading microvascular complication of DM, with disabling neuropathic pain, sensory/motor deficits and associated psychosocial disturbances.This short communication was aimed at exploring the role of energy metabolism in the pathogenesis, diagnosis and therapy for DPN and found evidence for altered lipid metabolism, with persistent anerobic glycolysis in peripheral nerves of DPN and efficacy of alpha-lipoic acid supplementation in DPN.  

Keywords: Metabolic neuropathy; Nutritional Endocrinology; Energy metabolism; Diet Neurology.