Females are more susceptible to periodontal diseases because of the influence of sex 
hormones in the body. These sex hormones are believed to be risk factors for periodontitis 
because of their ability to proliferate specific periodontal micro-organisms and affect the host 
immunologic response. The aim of the study was to compare the gingival status of female 
patients at menstrual age and pre-menopausal age. Materials and Methods - The study sample 
comprised of 50 female patients divided into 2 groups. Group A consisted of 25 subjects aged 
20-25 years and Group B consisted of 25 subjects aged 45-50 years. The clinical parameters 
like GI, PI and BIwere recorded for all the patients. Results wereobtained, and 2 groups were 
compared based on collection and the statistical analysis of the data. Statistical analysis of data 
were carried out using mean ± standard deviation (SD), p–value, t–test between two groups; 
For GI, PI and BI there was a highly significant difference between both the groups. It was 
concluded thatpremenopausal women had a greater chance of having gingivitis as compared 
with the menstrual age group.