Background: To see effect of low dose fentanyl vs low dose dexamethasone in ultrasound guided supraclavicular block via multipoint injection technique. Methods: This double blinded randomized controlled study was carried out on 60 patients belonging to ASA grade I and II, undergoing surgeries of the upper limb under USG guided supraclavicular block via multipoint injection technique. Group I (NS) received 20 ml 0.5% bupivacaine with 1 ml normal saline. Group II (Fenta) received 20 ml 0.5% bupivacaine with 10 µg (1 ml) fentanyl. Group III (Dexa) received 20 ml 0.5% bupivacaine with 4 mg (1 ml) dexamethasone. Results: The onset of sensory blockade in group 1 (NS) was 9.6430 ± 1.19025 min, in group 2 (Fenta) it was 10.3395 ± 0.59338 min, whereas in group 3 (Dexa) it was 3.9735 ± 0.41802 min. The onset of motor blockade was 17.9025 ± 1.13816 min in group 1 (NS), 17.9530 ± 0.85577 min in group 2 (Fenta), 8.6145 ± 1.15154 min in group 3 (Dexa). The mean duration of sensory blockade in group 1 (NS) was 259.200 ± 36.3544 min, in group 2 (Fenta) it was 406.350 ± 20.1240 min, whereas in group 3 (Dexa) it was 1031.500 ± 173.8676 min. The mean duration of motor block in minutes was 197.900 ± 31.8878 in group 1 (NS), 339.250 ± 26.2616 in group 2 (Fenta) and 934.950 ± 168.9181 min in group 3 (Dexa). Conclusion: The dosage of fentanyl and dexamethasone do not linearly correlate to the degree of blockade. Dexamethasone is superior to fentanyl as an adjuvant in supraclavicular block.