Introduction: Improvements in surgical training, as well as developments of instruments, imaging, and surgical techniques, have made laparoscopic surgery safe and feasible across different medical fields. It has its own advantages as it is minimally invasive with less postoperative pain, more rapid recovery, shorter hospital stay and earlier return to normal activity. Aims: The objective of the present study is to compare the efficacy of a single shot ultrasound guided Transversus Abdominis plane block with 0.375% Ropivacaine and 0.25% bupivacaine in providing post operative analgesia upto 24 hours for laparoscopic surgeries. Materials and Methods: It is a prospective, randomized, double blinded study in 60 adult patients including both males and females belonging to American Society of Anesthesiologist (ASA) I & II were included in the current study. Results: Bupivacaine and ropivacaine provided equally effective analgesia with TAP block till 24 hours after the block. There is also no significant difference in hemodynamics and sedation scores in between the groups. In both the groups the mean, duration of time taken for the pain score to be >4 (moderate pain) by numerical rating scale was around 15 hours after the block. Only seven patients (23.3%) in bupivacaine group and nine patients (30.0%) in ropivacaine group received the rescue analgesic once. Regarding the duration of analgesia both the drugs provided equally effective analgesia till the end of observation period i.e., 24 hours post operatively. Conclusion: Bupivacaine and Ropivacaine in laparoscopic surgeries showed that both (0.25%) bupivacaine and (0.375%) ropivacaine provided equally effective postoperative analgesia, better pain scores and required less doses of rescue analgesics in the first 24 hours duration after the block.