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Indian Journal of Anesthesia and Analgesia

Volume  5, Issue 12, December 2018, Pages 2053-2061


Original Article

Comparison of Dexmedetomidine with Esmolol as Hypotensive Agents in Elective ENT Surgeries in General Anaesthesia: A Randomized Controlled Trial
Shilpa Bansal1, Mridul M. Panditrao2,Sumit Bansal3, Minnu M.Panditrao4
1,3Assistant Professor 2Professor & Head 4Professor, Department of Anaesthesiology and Intensive Care, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab 151109, India.
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  Objective: To compare the efficacy of dexmedetomidine as a hypotensive agent with esmolol in elective ENT Surgeries in ASA grade I­II patients. Methods: This study was a prospective, randomized, double blinded study that included 60 ASA grade I and II patients, undergoing ENT surgeries 30 patients in each group. They were allocated to receive either esmolol (Group E) or dexmedetomidine (Group D) to maintain mean arterial blood pressure (MAP) between (55­65 mmHg). Intraoperative analgesic and additional hypotensive agent requirements were recorded. Standard Average Category Scale (ACS) was used for assessment of blood loss intraoperatively. Hemodynamic variables, emergence time, postoperative recovery time and sedation score following tracheal extubation were recorded. Post­operative pain, nausea and vomiting score and time needed to first analgesic were also recorded. Independent student T test was used for comparision of continuous variables and Chi square test for categorical variables. A P value of < 0.05 was considered statistically significant. Result: There were no inter group differences in haemodynamics and ACS. Emergence time, postoperative recovery and sedation score were significantly higher in Group D. VAS score was significantly lower in Group D. Time to first analgesic request was significantly longer in Group D. No postoperative nausea or vomiting was observed in both groups. Conclusion: Both dexmedetomidine and esmolol were effective in providing ideal surgical field. Both were safe agents for controlled hypotension. Dexmedetomidine offers the advantage of analgesia, amnesia and sedation with better intraoperative and postoperative patient satisfaction as compared to esmolol. 

Keywords: Dexmedetomidine; Esmolol Hydrochloride; Controlled Hypotension; ENT Surgeries.

Corresponding Author : Shilpa Bansal, Assistant Professor, Department of Anaesthesiology and Intensive Care, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab 151109, India.