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Indian Journal of Anesthesia and Analgesia

Volume  5, Issue 12, December 2018, Pages 2013-2020


Original Article

A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries
Girish B.K.1, Srinivas H.T.2, Shwetha M. Reddy3, Archana K.N.4
1Assistant Professor 2Associate Professor 3PG Resident 4Professor, Department of Anesthesia, JSS Medical College and Hospital, Karnataka 570015, India.
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  Background: Subarachnoid block is popular and commonly used worldwide. The advantage of an awake patient, minimal drug cost and rapid patient turnover has made this the method of choice for many surgical procedures. Among the popular drugs used for subarachnoid block are bupivacaine and and its enantiomer Levobupivacaine. Objectives: A clinical study to compare the effect of spinal anaesthesia with 0.5% hyperbaric levobupivacaine and 0.5% hyperbaric bupivacaine in patients undergoing elective below umbilical surgeries. Materials and Methods: 60 patients of American Society of Anaesthesiologists physical status class1 and 2 patients with 18 to 70 years of age posted for elective lower limb surgeries under subarachnoid block technique were randomly assigned into 2 equal groups. Group L received intrathecal hyperbaric 0.5% levo bupivacaine [total 3.5ml], Isobaric levobupivacaine made hyperbaric by adding 0.5ml of 50% dextrose to 3ml of levobupivacaine, Group B received intrathecal 15mg hyperbaric 0.5% bupivacaine with 0.5ml of normal saline.[total 3.5ml]. Results: Group L and Group B had similar onset of sensory blockade. Group L had delayed onset of motor blockade, lesser degree of motor blockade and lesser quality of intraoperative anaesthesia, similar level of sensory and maximum upper spread of sensory blockade, time  taken for two segment regression time and duration of motor blockade but shorter duration of analgesia when compared to Group B. Conclusion: Hyperbaric 0.5% bupivacaine remains effective choice than hyperbaric 0.5% levobupivacaine for spinal anaesthesia in elective surgeries, But hyperbaric levobupivacaine is also a better option for shorter procedures and outpatient spinal anaesthesia.

Keywords: Hyperbaric; Bupivacaine; Levobupivacaine; Subarachnoid Blockade.

Corresponding Author : Srinivas H.T., Associate Professor, Department of Anesthesia, JSS Medical College and Hospital, Karnataka 570015, India.