Background and Aims: Propofol is widelyused for induction andmaintenance of anaesthesia. It has the disadvantage of causing sharp pain on injection which can interfere with smooth induction of anaesthesia. The aim of the study was to compare the incidence and intensity of injection pain with medium chain triglyceride/ long chain triglyceride (MCT­LCT) propofol and long chain triglyceride (LCT) propofol during intravenous induction of anaesthesia. Methods and Material: Two hundred adult patients belonging to ASA physical status I or II, scheduled for elective surgeries under general anaesthesia were selected and randomly allocated to two groups L and M. Group L received 3 cc of LCT propofol and Group M received 3ccof MCT­LCT  propofol . Patients were observed and questioned after 30sec of injection and pain was scored on a 4 point scale. Pain recall was done on the same 4 point scale 30 minutes postoperatively. Statistical Analysis: Data was collected and analysed using Fisher’s exact test and unpaired t test. Statistical significance was taken as p< 0.05. Results: Both the incidence and intensity of pain was greater in group L compared with group M (p=0.0002). The mean pain score was also higher in group L (2.71) when compared with group M (1.08). The difference between two groups with regard to recollection of pain on injection of propofol was statistically significant (p=0.0001). Conclusion: Propofol MCT­LCT reduces both intensity and incidence of pain on injection.