Context: Many agents are being tried to prevent acute changes in hemodynamics taking place during surgery as a result of intubation and other invasive procedures. Over the period of time dexmedetomidine has evolved as safe and hemodynamically stable anesthetic agent over most of the other agents. Aims: To study efficacy of dexmedetomidine over oral pregabalin in patients undergoing laparoscopic cholecystectomy. Settings and design: Present study was prospective randomized controlled study carried out at Apollo hospitals, Jubilee Hills, Hyderabad. Material and methods: 50 eligible patients undergoing laparoscopic cholecystectomy as per study criteria were divided randomly into two groups. One group with 25 patients received dexmedetomidine (Group D) and other group with 25 patients received oral pregabalin. Both the groups were compared for mean arterial pressure and heart rate from pre­operative period till post­operative period. Statistical analysis: Students t test was used to find the association between two mean. p value less than 0.05 was taken as statistically significant. Results: Both the groups were comparable to each other in terms of baseline characteristics. Pre­operative mean arterial blood pressure and heart was also comparable between the two groups. But it was significantly lower in group D compared to group P right from induction to extubation. Conclusion: We hereby conclude that dexmedetomidine is superior to oral pregabalin and provides better hemodynamic stability to patients undergoing laparoscopic cholecystectomy.