Background and Aims: Total abdominal hysterectomy (TAH) is one of the commonly performed major surgical procedures resulting in substantial postoperative pain and discomfort. Hence, the study was carried out to compare the postoperative analgesic effect of Ropivacaine hydrochloride with Bupivacaine hydrochloride in transversus abdominis plane (TAP) block after total abdominal hysterectomy (TAH). The primary objective was to compare the post operative analgesic duration and secondary objective was comparing the hemodynamic parameters, nausea and sedation score. Methods: The Prospective, double blind and randomized comparative trial was conducted in 60 ASA physical status I and II patients scheduled for elective total abdominal hysterectomy. Patients were randomly divided into two group R and group B and they were given TAP block by ‘double pop off ’ technique with Ropivacaine and Bupivacaine respectively. Heart rate, systolic and diastolic blood pressure, NRS NRS nausea and sedation score were measured. Data was analysed with Mann Whitney U Test and Chi square test. Results: Haemodynamic variables like heart rate, systolic and diastolic blood pressure does not show significant difference with p value > 0.05. Time for rescue analgesia was significantly higher in patients with group B when compared with group R with p value of < 0.001. Nausea and Sedation score also remains normal without any significant changes with p value > 0.05.

Conclusion: Bupivacaine hydrochloride gave longer duration of postoperative analgesia compared with Ropivacaine hydrochloride and there is no significant differences in hemodynamic variables, nausea and sedation score.