Context: Atracurium is associated with hemodynamic instability in patients. Cisatracurium has been developed to overcome this side effect which is an isomer of atracurium. Aim: To study the efficacy of Cisatracurium in patients undergoing lower abdominal surgeries. Settings and Design: Present randomized controlled trial was conducted at Department of Anesthesiology, Malla Reddy Institute of Medical Sciences, Hyderabad. Methods: The patients being operated for lower abdominal surgeries were randomly allocated into two groups. 30 patients were in Atracurium group while 30 patients were in Cisatracurium group. The changes in the heart rate and mean arterial pressure was observed after giving injection of anesthetic and immediately after the intubation. Statistical analysis: The data was analyzed using means and proportions. Student’s t test for means and chi square for proportions was used. Results: Both the groups were comparable in baseline characteristics. The baseline heart rate was similar for both the groups. But heart rate after injection and after intubation in Atracurium group was significantly more compared to the heart rate after injection in Cisatracurium group (p < 0.05). The change of mean MAP was significantly more in Atracurium group after giving injection from baseline compared to Cisatracurium group. But the difference of means of change in MAP from giving injection to intubation was statistically not significant between the two groups (p > 0.05). Again the change in mean MAP was significantly more in Atracurium group after intubation from baseline compared to Cisatracurium group. Conclusion: Cisatracurium was found to be more effective than Atracurium in terms of stabilized heart rate and mean arterial pressure.