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Indian Journal of Anesthesia and Analgesia

Volume  5, Issue 7, July 2018, Pages 1239-1246


Original Article

A Prospective Randomised Control Study to Compare Hyperglycemic Stress Response to General Anaesthesia in Non Diabetics and Controlled Diabetics Posted for Elective Surgical Procedures
Pacharla Indira1, Rajola Raghu2, B. Deeprajsingh3
1Assistant Professor 2Associate Professor 3Professor, Dept. of Anaesthesiology, Osmania General Hospital / Osmania Medical College, Hyderabad, Telangana 500095, India.
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Diabetic patients presenting for elective surgical procedures will place an increasing burden on anaesthetic services. The effects of surgical stress and anesthesia result in a a hypermetabolic stress response, referred to as “stress hyperglycemia”. The aim of the study is to compare stress response to general anaesthesia by measuring the rise in blood glucose levels in controlled diabetics posted for elective surgical procedures in comparision with non-diabetic patients .Study was conducted in Department of Anaesthesiology, Osmania Medical College/Hospital, Hyderabad during 2010- 2012 in Fifty ASA Grade I & Grade II patients. Institutional Ethics Committee has approved the study, written and informe consent was obtained from the patients. The study population were in the age group of 35-55 years, of either sex divided into two groups scheduled for elective surgical procedures of 2 hours of duration (viz., laporatomy, thyroidectomy). A Opiod (Fentanyl) and Propofol based balanced general anaesthesia technique adequately attenuates Hyperglycemic Stress Response in Controlled Diabetics.

Keywords: Stress Response; Chronic Hyperglycemia; General Anaesthesia; Opioids; Cortisol; Hypothalamo-Pituatory Adrenal Axis (HPAA Axis); Diabetes Mellitus.

Corresponding Author : Pacharla Indira, Assistant Professor, Department of Anaesthesiology, Osmania General Hospital/Osmania Medical College, Hyderabad, Telangana 500095, India.