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Indian Journal of Anesthesia and Analgesia

Volume  5, Issue 7, July 2018, Pages 1210-1214


Original Article

A Comparative Study between Intrathecal Bupivacaine with Clonidine vs Bupivacaine with Neostigmine for Vaginal Hysterectomies: A Randomized Double Blinded Study
M. Santhi Sree1, N. Krishna Veni2
1Associate Professor 2Senior Resident, Department of Anaesthesia, Siddhartha Medical college, Vijayawada, Andhra Pradesh 520008, India.
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Introduction: Vaginal hysterectomy is the most common surgery done under spinal anaesthesia. The combination of local anaesthetics with adjuvants is getting more popular for better post-operative analgesia.

Aim: The purpose of our study is to evaluate and compare the addition of clonidine and neostigmine to intrathecal bupivacaine for prolongation of post-operative analgesia.

Materials & Methods: This was a prospective, randomized, controlled, double blind study carried out in patients undergoing vaginal hysterectomies. 50 patients of ASA grade I & II between 45-60years of age were assigned to 2 groups. Group BC: received 0.5ml of intrathecal clonidine (75g) along with 2.5ml of 0.5% Bupivacaine Group BN: received 0.5ml of intrathecal neostigmine(50g) along with 2.5ml of 0.5%bupivacaine.

Results: Sensory block onset, level of sensory block, duration of analgesia, motor block onset, duration of motor block, degree of motor block and recovery from motor block and incidence of side-effects are evaluated.

Conclusion: We concludefrom our study that intrathecal neostigmine 50g added to 12.5 mg hyperbaric bupivacaine significantly hastens the onset of sensory and motor block when compared to 75g clonidine and duration of analgesia is more prolonged with clonidine than neostigmine.

Keywords: Neostigmine; Clonidine; Post-Operative Analgesia.

Corresponding Author : M. Santhi Sree, Associate Professor, Department of Anaesthesia, Siddhartha Medical college, Vijayawada, Andhra Pradesh 520008, India.