Background and Aims: Selection of inhalational anaesthetic agents are based on their safety, emergence and recovery characteristics and side effects. This study was to assess the emergence and recovery characteristics and side effect profile of desflurane and sevoflurane.
Methods: 110 patients undergoing general anaesthesia for procedures below two hours were randomly assigned into two equal groups (n = 55). After intravenous induction, anaesthesia was maintained with 1.0 MAC (Minimum Alveolar Concentration) of desflurane (Group D) or sevoflurane (Group S) which was discontinued on skin closure. In Post-Anaesthesia Care Unit (PACU) patients were assessed by Modified Aldrete Scoring System and the emergence time was noted as the time to respond to verbal command. Patients were then assessed by Modified Post Anaesthetic Discharge Scoring System (PADSS) for their recovery from anaesthesia. Post-anaesthesia complications if any were also recorded. All parametric data were statistically analysed using Student’s t-test and non-parametric data by Chi-square test.
Results: Both groups were similar demographically with respect to age and sex (p > 0.05). Administration of desflurane resulted in faster emergence than sevoflurane (19±3.7 min vs. 27.04±6.7min, p < 0.01). The early and delayed recovery time were faster with desflurane than sevoflurane with P< 0.01. Side effects were also lesser with Group D when compared to Group S.
Conclusion: Desflurane was found to be superior to sevoflurane as inhalational anaesthetic agent for short surgical procedures in terms of its faster emergence and rapid recovery with minimal side effects.
Keywords: Desflurane; Sevoflurane; Emergence; Recovery.Corresponding Author
: Ramya T., Senior Resident, Department of Anaesthesiology, Government Medical College, Kozhikode, Kerala 673008, India.