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Indian Journal of Anesthesia and Analgesia

Volume  5, Issue 7, July 2018, Pages 1101-1107

 

Original Article

Effects of Oral Clonidine Premedication on Spinal Subarachnoid Blockade with Hyperbaric Bupivacaine
Bitan Sen1, A.R. Chaudhari2, Jayashree Sen3
1Post Graduate Student 2Professor 3Professor, Department of Anaesthesia, Jawaharlal Nehru Medical College, Acharya Vinova Bhave Rural Hospital Sawangi, Wardha, Maharashtra 442005, India.
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http://dx.doi.org/10.21088/ijaa.2349.8471.5718.3

Abstract

Background: The prolongation of local anesthetic induced sensory and motor block after co-administration with intrathecal clonidine [1,2] is well documented, but with oral clonidine the effect remains controversial [1.3].

Aim: To assess the effects of oral clonidine premedication in bupivacaine spinal anaesthesia (SA).

Materials and Methods: 40 patients of ASA I & II undergoing spinal anesthesia were randomly divided into two groups of 20 each. Group C: Oral clonidine 150µg premedication 90mins before SA with15 mg of 0.5% Bupivacaine heavy. Group P: SA with15 mg 0.5% bupivacaine heavy. 

Result: The time of onset of sensory blockade in group C was 2.95±0.68 min and in group P 6.75±0.71 min [p<0.0001], duration was 370.55±39.10 min in Group C and 253.50±43.95 min in Group P [p<0.0001]. The duration of motor block was 296.45±33.15 min in Group C and 196.3±32.7 min in Group P [p<0.0001]. No significant difference was found on demographic data, hemodynamic parameters and frequency of complications.

Conclusion: Pre medication with 150 µg oral clonidine in bupivacaine spinal block, can be instituted to prolong the duration of both sensory and motor blockade n routine practice without the fear of added complications.

Keywords: Oral Clonidine; Bupivacaine; Spinal Anaesthesia; Sensory Blockade; Motor Blockade.

 


Corresponding Author : Jayashree Sen, Professor, Department of Anaesthesia, Jawaharlal Nehru Medical College, Acharya Vinova Bhave Rural Hospital Sawangi, Wardha, Maharashtra 442005, India.