Objective: Sepsis is a problem that presents a management challenge and its early recognition and intervention clearly improves the outcome. Development of cost effective clinical parameters that would effectively prognosticate the outcome of sepsis would be invaluable. Shock Index, defined as ratio of heart rate (HR) and systolic blood pressure (SBP) may be a good non invasive measure of haemodynamic instability than HR and SBP alone. We conducted a study- 

1. To calculate shock index in patients with severe sepsis and septic shock at 0, 2 and 6 hours of admission.

2. To assess whether shock index (SI) at 0, 2 and6 hours has any prognostic significance in patients of severe sepsis and septic shock.

Methods: Records of 57 patients from August 2015 to January 2016 were collected from Medical Records Department of the hospital and clinical data recorded. Shock index (SI) was calculated at 0, 2 and 6 hours. The patients were divided into two groups according to their outcome as Survival or Death. Mann Whittney test, Pear on coefficicent and Kaplan Mieir Survival analysis curve were used for calculations.

Results: SI at 2 and6 hours significantly predicts mortality with pvalue of 0.001 and 0.0014 respectively. The best Predictor of mortality is where SI at 2 hours or 6 hours is greater than their cut off points.

Conclusion: From the present study, it may be concluded that SI at 2,6 hours was clinically relevant and easily calculated predictor of mortality.