Aim: The present study was conducted to evaluate the efficacy and analgesic effect of mixture of midazolambupivacaine as compared to bupivacaine alone in patients undergoing lower limb and lower abdominal surgeries under subarachnoid block.

Materials and Methods: The present study was conducted on 100 patients aged between 18 to 60 years belonging to ASA Grade I and II of both the sexes posted for lower limb and lower abdominal surgeries.

Results: In 100 patients duration of sensory blockade in both group B and group M. the mean duration of sensory blockade in group B is 89.1±2.95 minutes were as in group M, it is 118.94±10.83 minutes, p<0.05, hence statistically significant. (t = 18.5918, p= 0.000, statistically significant). The mean duration of maximum motor blockade in B is 163.3±16.6 with a range being 135 to 210 minutes. In group M, the mean duration of maximum motor blockade is 180.24±27.40 minutes with a range being 152 to 245 minutes. As p value is 0.0004 it is statistically significant. (T=3.693, P value0.0004, highly significant). In group B, the mean duration of analgesia is 125.46±7.18 minutes with a range of 110 to 142 minutes. In group M, the mean duration of analgesia is 243.26±24.41 minutes with a range of 173 to 273 minutes. In group B, the mean VAS score is 3.98±1 and in group M, it is 3.6±0.6. The t value is 2.869 and the p value is 0.005, hence there is statistical significance between them.

Conclusion: It can be inferred that inj. midazolam 1 mg in combination with inj.bupivacaine 0.5% hyperbaric can be safely administered intrathecally for better postoperative analgesia.