Aims: To compare Platelet indices with SOFA scores of patients with sepsis in order to assess the relationship between platelet indices like MPV and PDW and the severity of sepsis. Settings and Design: A total of 100 patients with sepsis or septic shock as cases and 95 patients as controls (with out sepsis) were considered for this study. Patients and Methods: The SOFA scoring of the patients (both cases and controls) was done at the time of admission. The relationship between platelet indices and severity of sepsis obtained by prognosis of the patient using admission SOFA score was assessed. Statistical Analysis: Statistical analysis was performed using SPSS for Windows version 17.0. Results: In patients with sepsis, there was a significant difference (P<0.05) between the baseline values of platelet counts as well as platelet indices amongst the two groups. Conclusion: The findings of this study suggest that platelet indices are significant indicators of severity of sepsis. Intense supervision and aggressive treatment of sepsis patients with higher baseline platelet indices may prevent progression of disease.