Introduction: Chemically induced tranquillity improves acceptance of Regional Anaesthetic techniques. Intravenous sedative medications are useful for the same as positioning for surgery can be uncomfortable and spontaneous movements by an inadequately sedated patient can cause interference with the surgical procedure. To allay this problem, sedation remains as inevitable modality. Objectives: Comparison of the sedation properties and efficacy of Dexmedetomidine with Midazolam when used for intraoperative sedation during Regional Anaesthesia. Methods: Prospective, randomized study was carried out in 100 patients of ASA grade 2 & 3, above 60 years of age, weighing 40 to 90 Kg, of both genders, scheduled for elective procedures. In our study, patients were divided into 2 groups of 50 each with the help of a computer generated table of random numbers. They received either Dexmedetomidine or Midazolam intravenously during Sedation for Regional Anesthesia. Accordingly patients receiving dexmedetomidine were classified as group X1 and those receiving Midazolam as group X0. HR, MAP recorded in all patients and compared. Result: HR and MAP in Dexmeditomidine group is significantly low than Midazolam group. Conclusion: Dexmedetomidine can be considered superior than Midazolam as a sedative agent for sedation under Regional Anaesthesia in Elderly patients.