Objective: To evaluate the efficacy and to compare the quality of peribulbar block anaesthesia of 0.5% Levobupivacaine, 0.5% Ropivacaine and 0.5% Bupivacaine for cataract surgery in post surgical/ post chemotheraphy/ post radiotheraphy oncology cases. Place and Duration of Study: Chengalpattu Medical College, Chengalpattu. 2023 - 24. Study Design: Randomized Controlled Clinical Trial. Methodology: After obtaining approval from institutional ethics committee and written informed consent from all patients, a randomized controlled double blinded clinical trial was conducted on 30 ASA 3 oncology patients undergoing cataract surgery. Patients were randomly allocated into three groups. Group L, Group R and Group B of 10 each. Patients in Group L were to receive Levobupivacaine 0.5%, Group R 0.5% Ropivacaine and Group B 0.5% Bupivacaine. Haemodynamic variables (heart rate, systolic and diastolic BP) and the onset and duration of sensory and motor block, sensory regression time, Intraocular Pressure values were recorded and compared using ANOVA test. Conclusion: Levobupivacaine is better suited for phacoemulsion surgeries of Post Surgical/ post chemotheraphy/ post radiotheraphy oncology cases.