Objective: To compare the onset and duration of sensory and motor block, haemodynamic responses, side effects associated with administration of thoracic epidural Levobupivacaine (0.5%) and Ropivacaine (0.5%) for modified radical mastectomy. Place and Duration of Study: Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Kanchipuram. 2023 - 24. Study Design: Randomized controlled clinical trial. Methodology: After obtaining approval from institutional ethics committee and written informed consent from all patients, a randomized controlled double blinded clinical trial was conducted on 30 ASA 3 carcinoma breast cases undergoing modified radical mastectomy. Patients were randomly allocated into two groups. Group L and Group R of 15 each. Patients in Group L were to receive Levobupivacaine 0.5% and Group R 0.5% Ropivacaine. Haemodynamic variables (heart rate, systolic and diastolic BP) and onset and duration of sensory and motor block, sensory regression time were recorded and compared using unpaired T-test. Conclusion: Levobupivacaine is better suited thoracic epidural anaesthetic drug for modified radical mastectomy surgeries than Ropivacaine.