Background and Aim: Ultrasound guided transversus abdominis plane (TAP) block is a safe, effective analgesic technique for lower abdominal surgeries .This study is designed to compare dexamethasone and dexmedetomidine as adjuvants for TAP block in patients undergoing abdominal hysterectomy under spinal anaesthesia. Materials and methods: After ethics committee approval and informed written consent ,30 Patients were allocated into 2 groups each by randomized double-blind design using a computer generated randomization posted for abdominal hysterectomy under spinal anaesthesia . Group D1 received Inj Bupivacaine 0.25% 20ml + Inj Dexamethasone 4mg + 1ml normal saline in TAP Block on each side. Group D2 received Inj Bupivacaine 0.25% 20ml + Dexmedetomidine 25mcg+ 1ml normal saline in TAP Block on each side at the end of surgery under ultrasound guidance. Assessment parameters included hemodynamic, post operative VAS score, duration of post operative analgesia, total dose of post operative rescue analgesia and side effects. Results: There was no significant difference in Heart rate and Mean arterial blood pressure in both the groups. In the first 8 hr post operative VAS score was lower in GROUP D1compared to GROUPD2 (p < 0.05).Duration of post operative analgesia was longer in GROUP D1 compared to GROUP D2 (p<0.05).Total dose of post operative rescue analgesia consumption in 24hrs was lower in GROUP DI than in GROUP D2 (p<0.05) . No significant side effects were noted. Conclusion: Dexamethasone as an adjuvant to bupivacaine in TAP block has prolonged postoperative analgesia and has reduced requirement of rescue analgesia than dexmedetomidine following abdominal hysterectomy under spinal anesthesia