Introduction: Pain is a conscious experience that result from brain activity in response to a various stimulusand engages the sensory, emotional and cognitive process of the brain. Pain can be classified based on painphysiology, intensity, temporal characteristics, type of tissue affected, and syndrome.

Aims: A comparing adenosine as a perioperative analgesic as an adjuvant.Materials and Methods: It is a randomised double-blind and controlled comparative study was conducted infifty adult patients scheduled for various procedures under general anaesthesia. The patients in the age group of 25–50 years were taken for the study. Adenosine was compared with opioid (fentanyl) analgesia. The study involves n=25 study group n=25 control group.

Results: Control group received opioid analgesia injection fentanyl 2mcg\kg body weight started afterintubation. The mean duration of surgery in both groups ranged between 75–90 mins.In comparision perioperative infusion of adenosine showed statistically significant stabilisation of hemodynamicsintraoperatively and postoperatively over the control group. The VAS scoring suggested that adenosine group carried a good analgesic effect intraoperatively and postoperatively in comparison with control group.Thereare no significant side effects in adenosine group in comparison with control group.

Conclusion: The observation suggested that cumulative effect of adenosine infusion carried a good analgesic effect and hemodynamic stabilization in post operative period. In post operative period patients who received adenosine not required any opiod or analgesic supplementation.