Introduction: Myoclonus is a common problem during induction of anesthesia with etomidate. We evaluated the effect of Lignocaine pretreatment on the incidence and severity of myoclonus in our study. Methods: This is a prospective randomized double blind study. Sample size was calculated with power of study 80% and alpha error 5%, 96 patients of ASA physical status I and II, aged 18 to 60 years scheduled for elective surgery under general anesthesia were included into three groups L1, L2, L3. Before induction, patients were pretreated with
inj. 2% lignocaine 3 ml containing 40 mg, 50 mg, 60 mg diluted with normal saline depending on the random allocation by computer generated random number table. Patients were induced with 0.3 mg/kg etomidate within 30–60 sec, one minute after pretreatment with lignocaine. Patients were observed continuously for the time of initiation, grade and severity of myoclonus for 90 sec, Results: In our study, it was found that with Injection 2% lignocaine 60 mg IV 59.3%, 50 mg Lignocaine 37.5%, 40 mg Lignocaine group 9.3% of the patients had no myoclonus which was found to be significant p < 0.001. Conclusion: Both 2% IV Lignocaine 50 mg and 60 mg were effective in reducing the severity of myoclonus induced by Etomidate without causing side effects.