Context: Dexmetedomidine is  2 agonist used as adjuvant to spinal anesthesia for prolongation of sensory, motor block, postoperative analgesia. Aims: To study the effect of single-dose IV dexmetedomidine
on hemodynamic profile, sensory-motor block prolongation, sedation. Methods and Material: 100 adult patients of ASA 1 and 2 posted for elective infraumbilical surgery were included. They were randomly divided into 2 groups. Group D received intravenous dexmtedomidine 0.5 g/kg over 10 min slowly. Group M - 0.5 mg/kg over 10 mins. Both drugs were administered 15 min after spinal anaesthesia with 15 mg 0.5% intrathecal bupivacaine heavy. Vital data, duration of sensory and motor block, sensory regression, Ramsay Sedation score and side effects were evaluated. Results: Duration of sensory block
in Group D was 308 ± 20 min prolonged than Group M 200 ± 15 min. Duration of two segment regression time in Group D – 140 ± 8 min more than Group M 120 ± 6 min. Ramsay sedation score was slightly more for Group D without any respiratory depression. Patients of both groups remained hemodynamically stable through out with minimal side-effects. Conclusions: Intravenous dexmetedomidine significantly augments the sensory and motor block of intrathecal bupivacaine providing excellent sedation.